Tag Archives: reactive oxygen species

New Insights into Natural Diabetes Prevention

I recently cut fruit juice out of my husband’s diet. I told him I wasn’t going to buy it anymore for him because of a recent study that correlated the consumption of 3 servings of fruit juice per week with a 10% increased risk of diabetes. Even before reading this study, I hadn’t been a fan of juice because it contains the sugar of the fruit without the fiber that slows the absorption of sugar. On the flip side, consuming 3 servings of fruit per week can help reduce the risk of diabetes by 3%. Certain fruits like blueberries, grapes, and apples had an increased protective effect, due to antioxidant compounds located in the skin of these fruits.

So why are antioxidants helpful at preventing diabetes? Excessive consumption of carbohydrates and calories in general causes an overabundance of energy on a cellular level. Unless we are active enough to be burning this excess energy, it actually contributes to the production of free radicals that damage our cells. To protect themselves from this excess energy and subsequent damage, our cells reduce the number of insulin receptors on their surfaces. The result of this is insulin resistance, a prediabetic condition where the body makes extra insulin to try to get cells to remove excessive sugar from the blood stream, but the cells ignore this message.  This protective measure of the cells saves the cells from damage and possible destruction, but long term, insulin resistance can contribute to the development of not just diabetes, but also high blood pressure, cardiovascular disease, and kidney disease.

The solution is not to force the cells to take up the excess sugar from the blood stream, but to reduce the consumption of excess sugar, carbohydrates, and overall calories. Viewing insulin resistance as a defensive mechanism of cells helps us see why these dietary changes are so vital to preventing diabetes. Additionally, exercise increases the energy needs of cells and allows them to metabolize sugar without excessive damage from free radicals.

Finally, looking at insulin resistance in this way helps us understand why a number of antioxidants have been found to be useful in diabetes and insulin resistance. For instance, alpha lipoic acid is a powerful antioxidant that helps fight insulin resistance as well as having the potential to help diabetic neuropathy. Intake of minerals like zinc, copper, and manganese are commonly helpful to diabetics and prediabetics because they help the body make superoxide dismutase enzymes to neutralize free radicals. Understanding these mechanisms can help us make and stick to healthier dietary choices, especially at this time of the year when there are so many sugary temptations.


Alpha Lipoic Acid: Amazing Antioxidant for the Nervous System

Among antioxidants, alpha lipoic acid is unique because it is both fat and water soluble. This means it can work in more areas of the body than other antioxidants that either dissolve in water like Vitamin C or are absorbed into fat like Vitamin E. Alpha lipoic acid has another important role through increasing the recycling of other antioxidants like vitamin C, vitamin E, glutathione, and coenzyme Q10. We need antioxidants to protect our cells from damaging molecules known as free radicals. When antioxidants neutralize free radicals, they have to be recharged before they can act again. By acting as an antioxidant and recycling other antioxidants, alpha lipoic acid can help keep our bodies functioning properly and help prevent degenerative diseases, especially those affecting the nerves.

Alpha lipoic acid has gained a reputation for protecting the nervous system by preventing damage to the nerves from free radicals and other reactive oxygen molecules. It also seems to support healthy microcirculation around the nerves so that nerves, including those in the brain, can be properly nourished. There is some evidence that alpha lipoic acid may even help with regeneration of nervous tissues in certain cases by supporting sufficient energy production in the cells. Alpha lipoic acid has been studied most extensively for peripheral neuropathy due to diabetes, where the elevated blood sugar and reduced circulation causes nerve damage with diminished or abnormal sensation in the hands and feet. Diabetics may also benefit from alpha lipoic acid because it appears to help increase the body’s response to insulin. Alpha lipoic acid is also used to help protect the optic nerve in glaucoma. Alpha lipoic acid was also been shown to reduce migraine frequency and severity in a small study. This benefit may be due to alpha lipoic acid’s ability to improve blood vessel function rather than its neuroprotective actions.